Microdosing, beyond the sub-perceptual, for solving currently relevant complex procedural and social-emotional problems that require innovative solutions. [...] Warning: the serotonin system is involved in regulating energy metabolism, social status (including resource access priority such as to food and mates), and psychedelics may lead to a challenging re-evaluation of priorities... (Read more)
Outlines and expands on the psycho-social implications of the film [...] An original discussion about some of the science of how psychedelics work in the brain is offered–a critical feature which was largely left out of the film, possibly due to its complexity... (Read more)
The view that biochemistry had no stake in the brain was soon to change after a series of discoveries about serotonin in the early 1950s. [...] Psychosis and mania are characterized in part by an over-ascription of meaning, and depression with a lack of meaning, consistent with Woolley’s work on the hyper- and hypo-serotonergic effects on bipolar psychosis... (Read more)
REM dreams reflect the use of existing experience to solve cognitively challenging learning tasks requiring innovative solutions (Smith, 2012). We hypothesize that reasoning and working memory would be positively related to dream experiences of good fortune and success, and negatively related to experiences of misfortune... (Read more)
Failed resolution of trauma, and specifically disorganized attachment, expresses itself in a propensity for mystical experiences (unrelated to religious/spiritual beliefs), mediated by trait absorption. (Read more)
This study adds to the growing body of evidence that serotonergic psychedelics affect the dopamine system, implicating them in reward and motivation. This may partially explain anecdotal reports of psychedelics dramatically affecting those with symptoms of attention deficit... (Read more)
Some factors were found predicting occurrence of HPPD, including pre-existing tinnitus, "floaters," and trouble concentrating, but most importantly, anxiety and panic reactions during the experience. This lead to speculation of hallucinogen-induced PTSD symptomatology as a useful model for HPPD... (Read more)
LSD's potent anti-inflammatory, amyloid-clearing and neuroplastic effects, its ability stimulate semantic and episodic memory and maybe even prevent the effects of sleep loss on forgetting, as well as to increase what some scientists call brain complexity, make it a promising treatment approach for Alzheimer's disease and traumatic brain injuries. (Read more)
Confronting terminal illness can lead to a devastating sense of demoralization, loss of hope, meaning, desire for hastened death, depression, and anxiety. Terminal cancer is the second leading cause of death in the world. Cancer will take one in four of us, and almost half of us will face it—at least once, at a rate of 1.6 million people in the US alone every year... (Read more)
We are, every living one of us, tied together by an ancient biochemical link; one that predates the divergence of all major kingdoms of life. What began two and a half billion years ago in the primeval waters of the Archean Eon would one day come to be involved in almost all aspects of animal life. Could the origins of serotonin and its chemical cousins hold the answer to the unending mystery of what psychedelic experience is all about? (Read more)
PSYCHOACTIVE aims to bind diverging scientific and academic research to understand the roles of set and setting in mental illness, create original discourse on the effects of psychedelics in human biology, behavior, and perception, and provide new and better ways to think about, communicate, and use altered states of consciousness.
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