Psychoactive

Articles

Can You Feel It? On Psychedelic Microdosing

Microdosing, beyond the sub-perceptual, for solving currently relevant complex procedural and social-emotional problems that require innovative solutions. [...] Warning: the serotonin system is involved in regulating energy metabolism, social status (including resource access priority such as to food and mates), and psychedelics may lead to a challenging re-evaluation of priorities... (Read more)

D. W. Woolley, the Serotonin Hypothesis and the Genesis of Psychopharmacology

The view that biochemistry had no stake in the brain was soon to change after a series of discoveries about serotonin in the early 1950s. [...] Psychosis and mania are characterized in part by an over-ascription of meaning, and depression with a lack of meaning, consistent with Woolley’s work on the hyper- and hypo-serotonergic effects on bipolar psychosis... (Read more)

Does Dream Content Predict Cognitive Abilities?

REM dreams reflect the use of existing experience to solve cognitively challenging learning tasks requiring innovative solutions (Smith, 2012). We hypothesize that reasoning and working memory would be positively related to dream experiences of good fortune and success, and negatively related to experiences of misfortune... (Read more)

Multiple Functional Enhancements of Dopamine Signaling by LSD

This study adds to the growing body of evidence that serotonergic psychedelics affect the dopamine system, implicating them in reward and motivation. This may partially explain anecdotal reports of psychedelics dramatically affecting those with symptoms of attention deficit... (Read more)

Hallucinogen Persisting Perceptual Disorder – A Very Brief Summary

Some factors were found predicting occurrence of HPPD, including pre-existing tinnitus, "floaters," and trouble concentrating, but most importantly, anxiety and panic reactions during the experience. This lead to speculation of hallucinogen-induced PTSD symptomatology as a useful model for HPPD... (Read more)

Classical Psychedelics for Alzheimer’s and TBIs?

LSD's potent anti-inflammatory, amyloid-clearing and neuroplastic effects, its ability stimulate semantic and episodic memory and maybe even prevent the effects of sleep loss on forgetting, as well as to increase what some scientists call brain complexity, make it a promising treatment approach for Alzheimer's disease and traumatic brain injuries. (Read more)

Psychedelic Clinical Trials for Patients With Terminal Illness Set to Begin at St. Vincent Hospital

Confronting terminal illness can lead to a devastating sense of demoralization, loss of hope, meaning, desire for hastened death, depression, and anxiety. Terminal cancer is the second leading cause of death in the world. Cancer will take one in four of us, and almost half of us will face it—at least once, at a rate of 1.6 million people in the US alone every year... (Read more)

PSYCHOACTIVE

PSYCHOACTIVE aims to bind diverging scientific and academic research to understand the roles of set and setting in mental illness, create original discourse on the effects of psychedelics in human biology, behavior, and perception, and provide new and better ways to think about, communicate, and use altered states of consciousness.

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